Tony Hawk's Pro Skater 5 drops September 29th. Lil Wayne is a character in the game, so he joined Hawk as he previewed it on the Conan O'Brien segment Clueless Gamer.
Wayne is really enjoying himself here. It could be the thrill of seeing himself in a video game, and it could also something he got into before getting on air.
But whatever it was, he still had enough wits about him to beat Conan in a head to head match up. A tattoo of the other person was at stake, and Conan's Weezy ink left everyone more horrified than happy.